SBMLtoODEjax: efficient simulation and optimization of ODE SBML models in JAX
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Developing methods to explore, predict and control the dynamic behavior of biological systems, from protein pathways to complex cellular processes, is an essential frontier of research for bioengineering and biomedicine. Thus, significant effort has gone in computational inference and mathematical modeling of biological systems. This effort has resulted in the development of large collections of publicly-available models, typically stored and exchanged on online platforms (such as the BioModels Database) using the Systems Biology Markup Language (SBML), a standard format for representing mathematical models of biological systems. SBMLtoODEjax is a lightweight library that allows to automatically parse and convert SBML models into python models written end-to-end in JAX, a high-performance numerical computing library with automatic differentiation capabilities. SBMLtoODEjax is targeted at researchers that aim to incorporate SBML-specified ordinary differential equation (ODE) models into their python projects and machine learning pipelines, in order to perform efficient numerical simulation and optimization with only a few lines of code. SBMLtoODEjax is available at https://github.com/flowersteam/sbmltoodejax.
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