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08/21/2023
Estimation of treatment policy estimands for continuous outcomes using off treatment sequential multiple imputation
The estimands framework outlined in ICH E9 (R1) describes the components...
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02/24/2023
Use of multiple covariates in assessing treatment-effect modifiers: A methodological review of individual participant data meta-analyses
Individual participant data (IPD) meta-analyses of randomised trials are...
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09/27/2022
Phases of methodological research in biostatistics - building the evidence base for new methods
Although the biostatistical scientific literature publishes new methods ...
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06/08/2022
A simple principal stratum estimator for failure to initiate treatment
A common intercurrent event affecting many trials is when some participa...
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03/30/2022
A comparison of strategies for selecting auxiliary variables for multiple imputation
Multiple imputation (MI) is a popular method for handling missing data. ...
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03/21/2022
Improving clinical trial interpretation with Acceptability Curve Estimation (ACE)
Effective decision making from randomised controlled clinical trials rel...
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12/10/2021
Handling missing data when estimating causal effects with Targeted Maximum Likelihood Estimation
Causal inference from longitudinal studies is central to epidemiologic r...
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07/15/2021
Covariate adjustment in randomised trials: canonical link functions protect against model mis-specification
Covariate adjustment has the potential to increase power in the analysis...
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07/13/2021
Planning a method for covariate adjustment in individually-randomised trials: a practical guide
Background: It has long been advised to account for baseline covariates ...
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10/20/2020
Introducing the treatment hierarchy question in network meta-analysis
Background: Comparative effectiveness research using network meta-analys...
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05/01/2019
Handling an uncertain control group event risk in non-inferiority trials: non-inferiority frontiers and the power-stabilising transformation
Background. Non-inferiority (NI) trials are increasingly used to evaluat...
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07/24/2018
Bivariate network meta-analysis for surrogate endpoint evaluation
Surrogate endpoints are very important in regulatory decision-making in ...
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12/08/2017