research
∙
04/12/2023
Predicting subgroup treatment effects for a new study: Motivations, results and learnings from running a data challenge in a pharmaceutical corporation
We present the motivation, experience and learnings from a data challeng...
share
research
∙
02/04/2021
Eliciting judgements about dependent quantities of interest: The SHELF extension and copula methods illustrated using an asthma case study
Pharmaceutical companies regularly need to make decisions about drug dev...
research
∙
02/04/2021
Improving the assessment of the probability of success in late stage drug development
There are several steps to confirming the safety and efficacy of a new m...
research
∙
08/12/2020
Principal Stratum Strategy: Potential Role in Drug Development
A randomized trial allows estimation of the causal effect of an interven...
research
∙
11/26/2018
Identifying treatment effect heterogeneity in dose-finding trials using Bayesian hierarchical models
An important task in drug development is to identify patients, which res...
research
∙
11/24/2018
A multiple comparison procedure for dose-finding trials with subpopulations
Identifying subgroups of patients with an enhanced response to a new tre...
research
∙
06/22/2018
Estimating the treatment effect in a subgroup defined by an early post-baseline biomarker measurement in randomized clinical trials with time-to-event endpoint
Biomarker measurements can be relatively easy and quick to obtain and th...
research
∙
04/26/2018