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11/29/2022
Joint modelling of longitudinal and time-to-event data applied to group sequential clinical trials
Often in Phase 3 clinical trials measuring a long-term time-to-event end...
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02/24/2022
Combining the target trial and estimand frameworks to define the causal estimand: an application using real-world data to contextualize a single-arm trial
Single-arm trials (SATs) may be used to support regulatory submissions i...
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02/04/2021
Eliciting judgements about dependent quantities of interest: The SHELF extension and copula methods illustrated using an asthma case study
Pharmaceutical companies regularly need to make decisions about drug dev...
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02/04/2021
Improving the assessment of the probability of success in late stage drug development
There are several steps to confirming the safety and efficacy of a new m...
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11/13/2019
A Bayesian hierarchical model for bridging across patient subgroups in phase I clinical trials with animal data
Incorporating preclinical animal data, which can be regarded as a specia...
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07/03/2019